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In rare cases, individuals with reactive airways, including some asthma patients, may experience temporary bronchospasms or airway irritation after glutathione administration

doi: 10.1016/j.ejmech.2019.06.010 44

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additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N- hexanoic-Tyr-Ile-(6)-aminohexanoic amide (dihexa), a potent cognitive enhancing molecule that proved to be very stable, to be capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, is slowly cleared from the blood compartment, and is sufficiently BBB permeable