Notably, food intake reduction was not observed in dual knockout mice, further suggesting both receptors are implicated in feeding (44)
While glutathione synthesis is controlled by multiple factors, GCL is the main determinant, because the rate-limiting step is the cellular level of the amino acid cysteine
There are several clinically available drugs that promote browning, but all must be given as pills or injections, says Li Qiang, assistant professor of pathology and cell biology at Columbia University and co-lead author of the study in ACS Nano
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doi: 10.1001/jamaoncol.2023.2789 115 ChesneyJAPuzanovICollichioFASinghPMilhemMMGlaspyJet al