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In patients with moderate hepatic impairment (Child-Pugh score 7 to 9), the maximum recommended dosage is phentermine and topiramate extended-release capsules 7.5 mg/46 mg orally once daily

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The increased generation of reactive oxygen species resulting from mitochondrial dysfunction is in turn a driver of further mitochondrial dysfunction [53], creating a vicious cycle of pro-oxidative and pro-inflammatory activity

abdomen, thigh, and upper arm