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You cant take them if: You or a family member has a history of medullary thyroid carcinoma (MTC) or MEN 2 Youve had a serious allergic reaction to the active ingredient or any components of the medication Youre pregnant, planning to become pregnant, or breastfeeding Talk to your doctor before starting if you have a history of: Pancreatitis or kidney problems Severe digestive conditions like gastroparesis Diabetic retinopathy If you have any upcoming surgeries or procedures planned , make sure to tell your care team that youre taking a GLP-1 pill before scheduling