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In animal toxicology studies, no significant adverse effects have been observed even at doses far exceeding typical therapeutic ranges

The reaction appears to take place either through the formation of N 2 O 3 or the addition of NO to a glutathionyl radical formed during this reaction (Broniowska et al., S -nitrosothiol (SNO)

People with sensitive digestive systems or those who have experienced gastrointestinal issues with other medications may be more prone to diarrhea when using tirzepatide

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