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Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling

Some studies have shown that Bivalirudin seemed to be more efficacious and safer than unfractionated heparin(UFH) for patients undergoing ECMO and a significant reduction in the transfusion requirements of composite blood products in pediatric patients on ECMO (79, 80)