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In the SUMMIT trial, tirzepatide significantly reduced the risk of death from cardiovascular causes or worsening heart failure events in patients with heart failure with preserved ejection fraction (ejection fraction 50% and above) and obesity (BMI 30 kg/m 2 ), compared with placebo (HR 0.62

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However, some of the changes of the antioxidant genes in the aged mice are inconsistent, and the phenotype might be tissue specific

Popichak KA, Hammond SL, Moreno JA et al (2018) Compensatory expression of Nur77 and Nurr1 regulates NF-B-dependent inflammatory signaling in astrocytes