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Moreover, their effectiveness in the brain may be limited by their bioavailability, including an insufficient ability to cross the BBB and poor distribution in the brain regions, making it difficult for the antioxidant compound to reach target sites

Saner, Nicholas J., et al

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If exam findings point to a specific cause, they add focused tests: e.g., cortisol or prolactin for suspected hormone tumors, sex-hormone and ultrasound for possible PCOS, heart or kidney studies for fluid retention, or imaging of the pituitary/adrenal glands