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Furthermore, mRNA and protein expression of CCL11 were both downregulated after GSDMD knockdown in THP-1 cells, suggesting that the absence of GSDMD not only reduced the release of CCL11 through pyroptosis process but also directly inhibited the CCL11 production

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This mechanism is distinct from the previously postulated mechanisms for the inhibition of EPSPs by the activity of HCN channels (Magee, 1998

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