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Our findings raise an important question regarding the mechanism by which intravenously administered CGRP induces migraine aura, specifically in relation to the CSD

Lee CJ, Mao H, Thieu VT, Fernndez Land L, Thomas MK

Whereas it is unlikely that the topical preparation as such immediately and directly reaches the hair bulb region, it has been shown that drug delivery to the skin occurs also through the hair follicles [32]

Research suggests the peptide works through hormetic mechanisms where lower doses may trigger stronger adaptive healing responses in certain tissue types