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Below is a snapshot of some supporting research: In one very small study on five people with mild to moderate Parkinsons disease and three controls, a high dose of NAC (a total of 6,000 mg/day taken orally which diminished the bioavailability of the dose) for a period of 4 weeks led to an increase of cysteine levels and antioxidant measures (GSH/GSSGa ratio of the reduced to oxidized glutathione which relates to oxidative stress with higher ratio levels associated with healthier cellsand catalase), but it did not demonstrate any improvement in the oxidative stress measurements (4HNE and MDA) nor did it increase the level of glutathione in the brains

Kidney disease: Even mild kidney disease can result in reduced excretion of uric acid from the body

Eric Topol noted: None of them are proven

At the same time, those pursuing more intensive liver detoxification may require customized guidance from a healthcare provider