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Additionally, report any changes in digestion, persistent constipation, or new nutritional symptoms immediately, as these may signal the need for dose adjustment or additional dietary support

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The oral phosphodiesterase (PDE) 4B inhibitor is a successor to Boehringer's blockbuster therapy Ofev (nintedanib), which contributed 3.8 billion of its 27.8 billion revenues in 2025, and was approved in the US last October

Overall odds ratios from the random effects model (3.44) and common effect model (3.40) indicate that ROSE-010 is significantly better than a placebo ( Figure 5 )