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Of note, pantothenic acid (formerly vitamin B 5 ) is the precursor of coenzyme A, and pyridoxine (vitamin B 6 ), in the form of pyridoxal-5'-phosphate, is required for the conversion of tyrosine to 4-hydroxyphenylpyruvic acid that constitutes the first step in the biosynthesis of the benzoquinone structure of coenzyme Q 10

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Therapeutic dosing usually involves Vitamin B12 doses of 1000 mcg or more per day