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Baseline estimated renal function was normal (eGFR 90 mL/min/1.73 m2) in 66.2%, mildly impaired (eGFR 60 to 90 mL/min/1.73 m2) in 32.4% and moderately impaired (eGFR 30 to 60 mL/min/1.73 m2) in 1.4% of patients

Draw the water into a syringe, add it slowly down the inside wall of the vial (do not spray directly onto the powder), and let it dissolve on its own without shaking

Review article: drug hepatotoxicity

Weekly heart rate and blood pressure checks during the first 812 weeks of combined therapy allow early detection of any sympathomimetic effects

However, the physiological substrates of OCTN1 are still matter of discussion (Pochini et al., 2019 and Table 1)