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Melatonin Affects the Normal Hormonal Development and Functioning of the Female Reproductive Organs Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring peptide hormone secreted by the pineal gland and multiple extra-pineal tissues (e.g., uterus, ovaries, and placenta) involved in the regulation of response to darkness, immune responses, inflammation, and microenvironmental angiogenesis [108]