In some embodiments, the lipid-based drug delivery formulation or composition comprises a penetration enhancer (e.g., a low molecular weight alcohol (e.g., ethanol, oleyl alcohol), alkyl methanol sulphoxides, N-methyl-2-pyrrolidone, fatty amines (e.g., oleylamine), fatty acids (e.g., oleic acid, palmitoleic acid, linoleic acid, myristate acid), gluconic acid (the hexonic acid derived from glucose by oxidation of the aldehyde group at C-1 to a carboxyl group) and its derivatives, such as gluconolactone (especially, glucono-D-lactone, a chelating agent produced by the oxidation of glucose), azone and propylene glycol, singly or in combination)
30 LiuJ
Los datos disponibles provienen esencialmente de los estudios animales, donde el pptido ha mostrado generalmente un perfil de toxicidad muy favorable
doi: 10.1007/S00281-020-00831-Y 27 AnindyaRRutterGAMeurG
Psychiatry 78 : 702710 (2015)