In addition, xCT expression can be regulated by the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/PKB/mTOR) 29,30,31 and mitogen-activated protein kinase (MAPK) pathways in synergy with activating transcription factor 4 (ATF4), which is activated by endoplasmic reticulum stress
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Ultimately, multimodal interventions are likely feasible, tailorable to individual risk factors and preferences, and compatible with disease modifying therapies, suggesting that these approaches offer promise in the prevention and treatment of AD/ADRD
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