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J Clin Psychopharmacol (2005) 25:4859.10.1097/01.jcp.0000177667.35016.e9 111 KlaimanCHuffmanLMasakiLElliottGR

These 51 targets were imported into the STRING 12.0 database to generate the PPI network, which was then visualized using Cytoscape 3.10.0 software

& Popek, M

The present review highlights the strengths of providing a comprehensive synthesis of evidence on the role of estrogens and estrogen receptors in cognitive and mental health outcomes during menopause, integrating both preclinical and clinical findings

The general principle: larger body mass means more adipose tissue to mobilize, more volume of distribution for the compound, and potentially higher receptor density