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It begins with the biological signals your body receives in the first few hours after waking

DHODH activity is essential for proliferating cells owing to their increased demand for nucleotides, and DHODH inhibition has long been studied as a therapeutic strategy in autoimmune diseases (for example, via leflunomide) and cancer, where it can lead to cell cycle arrest, DNA damage and replication stress 42,44,45

The production of ROS is linked to the overexpression of a misfolded disulphidebonded protein, carboxypeptidase Y (CPY * )

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