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The efficacy and safety of acetyl-l-carnitine (500 mg three times a day) versus methylcobalamin (0.5 mg three times a day) to treat diabetic peripheral neuropathy was assessed in a Chinese multicentre, randomised, parallel-group, double-blind, double-dummy, positive-controlled, non-inferiority phase II clinical trial

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Some skin darkening is unavoidable even at low doses, but the effect is dose-dependent.

Severe or prolonged symptoms require medical assessment rather than another exposure