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doi: 10.1016/S2213-8587(15)00482-9 5 American Diabetes Association

Over-application does not necessarily yield faster or better results

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Possible mechanisms of renal protection with SGLT2 inhibitors are multifactorial and it is likely that reduction in the glomerular capillary pressure, and reduction in an initial hyperfltration, can contribute to the reduced albuminuria and prevention of renal impairment [62, 63]