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JAMA Intern Med 177:633640 Lincoff AM, Wolski K, Nicholls SJ, Nissen SE (2007) Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus a meta-analysis of randomized trials

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After you limit or test any of these items, make changes slowly, log reactions, and prefer smaller portions rather than abrupt eliminations, because individual tolerance varies

For instance, some protocols might explore higher doses for short, acute periods, while others favor lower, sustained dosing for chronic conditions

These predispositions should be interpreted with a qualified healthcare provider and do not predict exact medication response, but can support discussion about optimal dosing and formulation