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Neuropsychopharmacology 39:831840

This article may help you understand why this happens and how to reduce melanin in skin to manage this condition

Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters

However, high B12 levels in the blood can be a sign of underlying kidney or liver disease, indicating that these organs are struggling to get rid of excess B12