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To determine nonclinical efficacy, LY2112688 was subcutaneously administered to DIO rats at 0.075 and 0.3 mol/kg once-daily for 14 days (52)

172,173 For instance, the primary effect of SLC2A9 (rs12498742) explains 2% to 3% of serum uric acid level variance in Europeans, which is substantial for a complex phenotype