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We then compared all 1637 OTUs between the low- and high-TMAO producer groups and found 101 OTUs were significantly enriched in the high-TMAO producer group (FDR 10 M group (0 vs

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HO-1 facilitates the breakdown of heme, resulting in the release of significant quantities of reactive iron ions, which then promote the Fenton reaction, ultimately producing lipid peroxides and causing ferroptosis in osteoblasts ( Figure 3 ) (124, 136)