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This therapeutic effect has also been explored in patients with obesity and major depressive disorder, a population often affected by overlapping pathophysiological processes such as insulin resistance, inflammation, and altered reward system function [33,42,70]

Notably, exenatide immediate-release (Byetta) and lixisenatide (Adlyxin, and in Soliqua) do not carry this boxed warning or contraindication

Joana Nicolau has received fees for presentations and consulting on behalf of Sanofi, Novo Nordisk, Lilly, Boehringer-Ingelheim, Fresenius, AstraZeneca, Fresenius, Dexcom, Amgen, and Senseonics

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