Dehydration risk represents another consideration
A healthcare provider can help determine the most appropriate treatment duration based on individual goals and results
This is when GI effects are most pronounced, and heavy meals are most likely to trigger nausea
So far, serious side effects havent been common, but heres what an early phase 2 study has shown: Pancreatitis: Happened in about 0.4% of people in the study Gallbladder problems: Reported in about 1.1% of participants Heart rhythm changes: Seen more often with retatrutide, about 6% compared to 3% with placebo Liver enzyme changes: Around 1% of participants had increases, but overall liver health stayed stable These results suggest a low but real chance of serious issues such as pancreatitis, gallbladder problems, severe GI events, and allergic reactions
Better insulin sensitivity means more efficient nutrient partitioning, more glucose directed to muscle rather than fat, and better preservation of lean mass during caloric deficit