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One widely used inbred strain(BTBR T + Itpr3tf/J) BTBR miceexhibits behavioral phenotypes similar to patients with ASD (Endo et al., 2019)

By participating in NLRP3 and NF-kB related signalling pathways, empagliflozin, a new hypoglycaemic drug that can improve the prognosis of CVDs, can attenuate ferroptosis, fibrosis, apoptosis, and inflammation in doxorubicin-treated mice and significantly improve cardiac function, thereby opening up a new avenue for the treatment of doxorubicin-related cardiotoxicity [150, 151]

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Pathway enrichment analysis via KEGG, using differentially expressed proteins in each phase, identified significant metabolic pathway enrichment throughout development (Fig

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