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In the largest clinical trial that tested Wegovy before its FDA approval, people taking the highest dose (2.4 milligrams) lost, on average, more than 12% of their body weight over 17 months

Describing herself as largely 'the lab rat' when she joined the diabetes team, Knudsen remembers she spent 'the first year in a cold room with three technicians to screen hundreds of thousands of compounds to see if they could wedge into the GLP-1 receptor and other targets of interest just snugly enough to stimulate insulin secretion.' To help speed up the screening process, Knudsen devised a method to test 96 candidates in one go instead of just one