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The method of embodiment 53, wherein the composition comprises between about 0.01% to about 20% by weight of the carbomer, about 0.01% to about 15% by weight of the carbomer, about 0.01% to about 10% by weight of the carbomer, about 0.01% to about 7% by weight of the carbomer, about 0.01% to about 5% by weight of the carbomer, about 0.01% to about 3% by weight of the carbomer, about 0.01% to about 2% by weight of the carbomer, or about 0.01% to about 1% by weight of the carbomer

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Diabetes Care 36(10):29812987 Moore EM, Mander AG, Ames D, Kotowicz MA, Carne RP, Brodaty H, Woodward M, Boundy K, Ellis KA, Bush AI et al (2013b) Increased risk of cognitive impairment in patients with diabetes is associated with metformin