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LINZESS is available in a once-daily dose for the following indications 1 For adults with IBS-C: 290 mcg For adults with CIC 2 dosing options: 145 mcg and 72 mcg For IBS-C in pediatric patients 7 years of age and older: 145 mcg For FC in pediatric patients 6 years of age and older: 72 mcg For IBS-C* ICD-10 Diagnosis Code K58.1 2, For CIC* ICD-10 Diagnosis Code K59.04 2, For FC ICD-10 Diagnosis Code K59.04 2, CIC, chronic idiopathic constipation

Common mistakes that sabotage results Most failures in this combination come from predictable, avoidable errors

Phospholipid synthesis in mammalian cells, in Biochemistry of lipids, lipoproteins and membranes (Amsterdam, The Netherlands: Elsevier), 227258)

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Continuously improve and update Good laboratory practice regulations for nonclinical studies are constantly evolving