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Ex-4 inhibits mTOR, an autophagy inhibitor in tumor cells, by downregulating Akt and simultaneously activating AMPK, subsequently attenuating the phosphorylation of its major downstream targets, eukaryotic translation initiation factor 4e binding protein 1(4E-BP1) and ribosomal s6 kinase 1(S6K1)
Summary: There is no robust clinical evidence or UK regulatory guidance showing that Ozempic (semaglutide) directly lowers cortisol levels
PCOS (Polycystic Ovary Syndrome) How its suspected to work: - Reduces insulin resistance (a key driver of PCOS) - Promotes weight loss, which improves hormone balance - May lower testosterone and help regulate cycles - Reduces inflammation, which worsens symptoms Fatty Liver Disease (NAFLD/NASH) - Reduces liver fat by improving insulin sensitivity - Lowers inflammation and oxidative stress in liver cells - Helps with weight loss, which improves liver function Some GLP-1s are currently in trials for direct liver health benefits
Importantly, NSAIDs should generally be avoided in cirrhosis or advanced liver disease due to increased risks of renal impairment, gastrointestinal bleeding, fluid retention, and hepatic decompensation, as advised by NICE guidance (NG50: Cirrhosis in over 16s)
