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The impact of their molecular mechanisms has been evidenced by landmark trials, which have repeatedly demonstrated that certain GLP-1 RAsincluding liraglutide, semaglutide, and dulaglutideare particularly efficacious in reducing MACE, especially in patients with established ASCVD

P = 0.0006 for superiority) [60]

SattarNLeeMMYKristensenSLBranchKRHPratoDKhurmiSet alCardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials

doi: 10.1001/jamapsychiatry.2025.2332 12 GaoS

Bacteria identified on the GI360 panel, such as Akkermansia muciniphilia and Bifidobacterium, as well as polyphenol consumption and short-chain fatty acids, play a role regarding GLP1 activity