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And emerging research suggests direct effects on adipose tissue metabolism that may shift the body toward preferentially burning fat stores rather than lean muscle

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[55] Furthermore, semaglutide improves the brain's sensitivity to leptin, a hormone produced by fat cells that signals satiety to the brain

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The logic makes pharmacological sense: two half-doses separated by 3.5 days each would theoretically produce a flatter drug concentration curve with lower peaks and higher troughs