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Furthermore, fAD organoids exhibited signs of neuronal apoptosis, with increased levels of cleaved Caspase-3 (c-CASP3) and TUNEL signals, and mitochondrial dysfunction markers (NDUFA4, NDUFA6, NDUFB11) in Day 60 fAD organoids [2]

These antioxidant properties are associated with enhanced mitochondrial function and longevity-related gene expression, supporting research into anti-aging and cellular resilience mechanisms

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