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Though the body usually manufactures glutathione, environmental conditions, including pollution, stress, and poor food, can cause the body to lose glutathione

Akt also inhibits apoptosis by deactivating pro-apoptotic protein Bcl-2 antagonist of cell death (BAD), as well as by promoting the breakdown of p53 as a pro-apoptotic protein via activation of E3 ubiquitin-protein ligase MDM2 [79]

Therefore, each drug of abuse affects overall metabolism in a complex way and the metabolic changes can eventually contribute to damage to cells and organs that manifest as tissue damage and eventually to manifestation of increased ageing rate and diseases ( Is it possible to protect against/reverse the metabolic and epigenetic changes due to drug abuse

MCAS is linked with Dercums disease, connective tissue disease, obesity, chronic inflammation, diabetes, and Ehlers-Danlos syndrome