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Beyond glycemic effects, GLP-1 receptor agonists slow gastric emptying, which prolongs the sensation of fullness after meals and contributes to reduced caloric intake

The mechanism involves activation of AMPK pathways and improvement in mitochondrial function, which addresses metabolic dysfunction at a cellular level that GLP-1 agonists do not directly target

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Expert Guidance on Safe Consumption Levels Experts generally consider up to 400 milligrams of caffeine per day (about four cups of coffee) safe for most people

East Croydon Medical Centre NHS GLP-1 Medications and Oral Contraception or HRT (August 2025) 7