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guineense may be toxic, and excessive consumption of the leaves is not recommended (524)

Besides passive diffusion across bilayer membranes, uptake or efflux via membrane transporter molecules is of high significance for compound absorption, distribution and elimination ( metabolite was observed to be subjected to facilitated uptake via GLUT-1 transporters into erythrocytes and endothelial cells ( For Pycnogenol constituents and metabolites, interactions with some specific structures, such as matrix proteins ( in vitro

10.1002/jnr.20722 25 ItkinA.DupresV.DufrneY

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