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The intracellular pool of folates also is involved in the regulation of homocysteine metabolism by supplying 5-methylTHF

This complex disorder carries a genetic predisposition and is associated with abnormalities in pain mediators, such as substance P, and neurotransmitters, such as serotonin

Clinical guidelines currently recommend the use of hormonal drugs developed for contraception as first-line treatment for endometriosis-related pain: 13 of the marketed products fall in this category, though only some have received approval specifically for endometriosis, such as norethindrone and dienogest

the improvement of cardiac performance

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