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To date, several small molecule DPP-4 inhibitors (vildagliptin, sitagliptin, saxagliptin, lina-gliptin, and alogliptin) have been used as treatments for type 2 diabetes to improve glucose tolerance

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Additionally, indole-3-carboxylic acid (ICA), a metabolite derived from Lactobacillus gallinarum , has been shown to improve anti-PD-1 efficacy in mouse models with different microsatellite instability (MSI) statuses [104]

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