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The putative role of neuroinflammation in the complex pathophysiology of migraine: from bench to bedside

The key protease responsible for the processing of the proglucagon peptide into GLP-1 is Psck1/3, which has shown to be upregulated in -cells during hyperglycaemic, hyperlipidemic, or inflammatory conditions to promote glucose-induced glucagon suppression, a compensatory response to a metabolic insult as in type 2 diabetes (205)

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doi:10.3109/09513590.2015.1115974 71 Ooi, S