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For example, the REWIND trial for dulaglutide and the SELECT trial for semaglutide (obesity patients) show statistically significant reductions in heart attack, stroke, or cardiovascular death ( [19] )

The functional substitution worked, meaning the molecule genuinely switches the signal on

This study was published in 2013

Diabetes also increases the morbidity and mortality of these patients, by contributing to higher rates of infections, cardiovascular events, and malignancy