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Clinicians should exercise caution in patients with a history of pancreatitis or gastroparesis, inflammatory bowel disease, other gut motility disorders, medullary thyroid carcinoma, or Multiple Endocrine Neoplasia syndrome type 2, and pause therapy when clinically indicated, such as before anesthesia

Semaglutide treatment affects many of these domains simultaneously, making it challenging to isolate specific causative mechanisms

Researchers should always utilize appropriate personal protective equipment (PPE), including nitrile gloves, during handling

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Inconsistent delivery: Nasal congestion, user technique, and mucus can impact effectiveness