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Management: Limit use to 46 week cycles with at least equal time off Consider using GH peptides like GHRP2 or CJC1295 during off cycles to maintain baseline IGF-1 activity Risk of Unwanted Growth (Organs, Gut, Tumors) Long-term, excessive IGF1 can theoretically increase the risk of visceral organ growth , insulin resistance , or even tumor promotion , due to its role in cell proliferation