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Upon perfusion, OPTEC tubules displayed proper polarization and expressed a broad array of proximal-tubule-specific functional markers, exhibiting higher expression levels of basolateral drug transporters, namely organic cationic/carnitine transporter 2 (OCT2), organic anion transporter 1 (OAT1) and OAT3, compared to immortalized PTECs

For example, whereas sulphide-oxidising activity is virtually undetectable in nervous system cells, colonocytes display high expression and activity of SOP enzymes, 131,132,133 consistent with the high H 2 S concentrations that result from gut microbial metabolism

The mobile phase parameters were set according to the following gradient: 013 min of 80% to 20% of mobile phase B

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The findings are also supported by another similar study conducted on the effects of Diospyros lotus leaf extract against UVB-induced skin damage in BALB/c mice