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To maintain blinding during injections, participants wore blindfolds and listened to music through headphones so they could not hear the distinctive clicking sound of the semaglutide injection pen

Managing Constipation The slowed digestion that drives weight loss also slows movement through the colon

This is concerning because loss of skeletal muscle can lead to decreased strength, reduced functional capacity, and a lower resting metabolic rate, potentially making weight regain more likely after medication discontinuation

Patients should aim to drink 91-125 ounces of fluid daily

Plasma semaglutide concentrations were measured in plasma by a validated liquid chromatography-mass spectrometry assay following protein precipitation (Celerion Switzerland AG, Fehraltorf, Switzerland) using previously reported methods [18, 20] with a lower limit of quantification of 0.729 nmol/L