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Furthermore, obesity accounts for 44% of the diabetes burden, 23% of the ischemic heart disease burden and up to 41% of cancer burden globally [2]

In some embodiments, the otic formulation or composition comprises between about 0.001% to about 60% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Current FDA context: FDAs May 2026 assessment found no clinical studies establishing the safety of Epitalon free base or Epitalon acetate in humans, no pharmacokinetic data and no patient studies supporting its proposed use for insomnia

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