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A subgroup analysis showed greater efficacy in areas without fortified food or with only partial fortification

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These were secondary, explorative outcome variables, and the number of patients to evaluate by the iohexol plasma clearance technique and hyperinsulinemiceuglycemic clamp was not calculated a priori on the basis of an expected treatment effect, but was dictated by feasibility, considering that both procedures are time- and cost-consuming and demanding for both patients and investigators

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