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This family of bacteria are able to metabolize primary bile acids into secondary bile acids, which then bind to TGR5 and stimulate GLP-1 secretion ( Akkermansia muciniphila significantly increases the ileal expression of Gcg and Pcsk1 , and oral glucose-stimulated plasma GLP-1 compared to mice fed the HFD alone (Yoon et al., 2021)

36(11-12) 761 | DOI : 10.1055/s-2004-826160

Who benefits most: Those who've hit a weight loss plateau despite consistent effort

There are some mechanisms by which tesofensine may contribute to increased fat burning such as increased metabolism, appetite suppression, and modulation of neurotransmitters

Further investigation of the actions of the CaSR in the area postrema may prove useful for developing new therapies targeting CACS and/or obesity.