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This lines up with what we see physiologicallyGLP-1 seems to shift autonomic balance toward sympathetic dominance, which fitness can partly buffer at the level of heart rate but not at the deeper vagal modulation reflected in HRV

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Addressing weight alongside these conditions can accelerate broader improvements in overall health

Sodium-glucose cotransporter protein 2 inhibitors (SGLT2-I) have been proven to be cardio-protective when administered in cases of heart failure